![]() Īpte, G., Repanas, A., Willems, C., Mujtaba, A., Schmelzer, C. Studies of cross-linking reaction on chitosan fiber with glyoxal. Journal of Materials Science: Materials in Medicine, 27(1), 1–11. Combined delivery of PDGF-BB and BMP-6 for enhanced osteoblastic differentiation. Journal of Materials Science: Materials in Medicine, 33(2), 1–16. Chitosan-collagen-hydroxyapatite membranes for tissue engineering. īecerra, J., Rodriguez, M., Leal, D., Noris-Suarez, K., & Gonzalez, G. Bone tissue engineering: State of the art and future trends. In vitro and in vivo studies of a gelatin/carboxymethyl chitosan/LAPONITE® composite scaffold for bone tissue engineering. Tao, L., Zhonglong, L., Ming, X., Zezheng, Y., Zhiyuan, L., Xiaojun, Z., & Jinwu, W. Optimizing nanohydroxyapatite nanocomposites for bone tissue engineering. Enhanced biomineralization and protein adsorption capacity of 3D chitosan/hydroxyapatite biomimetic scaffolds applied for bone-tissue engineering. Natural and synthetic polymers for bone scaffolds optimization. The results highlighted that glyoxal cross-linked scaffolds containing equal amounts of Chi and Coll by mass and 1% (w/v) nHA are the best candidates for osteoblast differentiation and matrix mineralization.ĭonnaloja, F., Jacchetti, E., Soncini, M., & Raimondi, M. The MC3T3‐E1 proliferation, osteogenic‐related gene expression, and matrix mineralization were better pronounced in collagen presence and triggered as collagen type I amount was increased. Glyoxal cross-linked structures displayed optimum mechanical and structural properties. The cross-linker type and collagen content had prominent effects on mechanical strength. All types of scaffolds displayed highly porous structures. Based on the physicochemical and mechanical characterization, the scaffolds were eliminated comparatively. The scaffolds were prepared by freeze-drying method and cross-linked using different types of cross-linkers. The scaffolds, composed of chitosan/collagen type I/nanohydroxyapatite (Chi/Coll/nHA) as the most attractive components in bone tissue engineering, were analyzed. Herein, a competitive approach was followed to point out an optimized bio-composite scaffold in terms of scaffold properties and stimulation of osteoblast differentiation. The combination of biodegradable natural polymers and bioactive ceramics that leverage potent bio-mimicking cues has been an active strategy to achieve success in bone tissue engineering. Bio-composite scaffolds mimicking the natural microenvironment of bone tissue offer striking advantages in material-guided bone regeneration. ![]()
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